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Publikationen des Lehrstuhls für Pharmazeutische Biologie

2018

F. Hillmann, G. Forbes, S. Novohradská, I. Ferling, K. Riege, M. Groth, M. Westermann, M. Marz, T. Spaller, T. Winckler, P. Schaap, G. Glöckner (2018). Multiple roots of fruiting body formation in Amoebozoa. Genome Biol. Evol., in press

2017

T. Spaller, M. Groth, G. Glöckner & T. Winckler (2017). TRE5-A retrotransposition profiling reveals putative RNA polymerase III transcription complex binding sites on the Dictyostelium extrachromosomal rDNA element. PLoS ONE 12(4): e0175729

R. Barnett, D. Raszkowski, T. Winckler & P. Stallforth (2017). Versatile synthesis of the signaling peptide glorin. Beilstein J. Org. Chem. 13, 247-250

2016

M. Dubiak-Szepietowskaa, A. Karczmarczyk, T. Winckler & K.-H. Feller (2016). A cell-based biosensor for nanomaterials cytotoxicity assessment in three dimensional cell culture. Toxicology 370, 60-69

T. Spaller, E. Kling, G. Glöckner, F. Hillmann & T. Winckler (2016). Convergent evolution of tRNA gene targeting preferences in compact genomes. Mob. DNA 7, 17

M. Dubiak-Szepietowska, A. Karczmarczyk, M. Jӧnsson-Niedziуłka, T. Winckler & K.-H. Feller (2016). Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicicty assessment in vitro. Toxicol. Appl. Pharmacol. 294, 78-85

2015

P. Schaap, I. Barrantes, P. Minx, N. Sasaki, R.W. Anderson, M. Bénard, K.K. Biggar, N.E. Buchler, R. Bundschuh, X. Chen, C. Fronick, L. Fulton, G. Golderer, N. Jahn, V. Knoop, L. Landweber, C. Maric, D. Miller, A.A. Noegel, R. Peace, G. Pierron, T. Sasaki, M. Schallenberg-Rüdinger, M. Schleicher, R. Singh, T. Spaller, K.B. Storey, T. Suzuki, C. Tomlinson, J.J. Tyson, W.C. Warren, E.R. Werner, G. Werner-Felmayer, R.K. Wilson, T. Winckler, J.M. Gott, G. Glöckner & W. Marwan.(2015). The Physarum polycephalum genome reveals extensive use of prokaryotic two-component and metazoan-type tyrosine kinase signaling. Genome Biol. Evol. 8, 109-125

A. Schmith, T. Spaller, F. Gaube, Å. Fransson, B. Boesler, S. Ojha, W. Nellen, C. Hammann, F. Söderbom & T. Winckler (2015). A host factor supports retrotransposition of the TRE5-A population in Dictyostelium cells by suppressing an Argonaute protein. Mob. DNA 6, 14

R. Otto, R. Penzis, F. Gaube, O. Adolph, K.J. Föhr, P. Warncke, D. Appenroth, C. Fleck, C. Enzensperger, J. Lehmann & T. Winckler (2015). Evaluation of homobivalent carbolines as designed multiple ligands for the treatment of neurodegenerative disorders. J. Med. Chem. 58, 6710-6715

B. Tewes, B. Frehland, D. Schepmann, D. Robaa, T. Uengwetwanit, F. Gaube, T. Winckler, W. Sippl & B. Wünsch (2015). Enantiomerically pure 2-methyltetrahydro-3-benzazepin-1-ols selectively blocking GluN2B subunit containing N-methyl-D-aspartate receptors. J. Med. Chem. 58, 6293-6305

F. Hillmann, S. Novohradská, D.J. Mattern, T. Forberger, T. Heinekamp, M. Westermann, T. Winckler & A.A. Brakhage (2015). Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation. Environment. Microbiol. 17, 2858-2869

2014

R. Otto, R. Penzis, F. Gaube, T. Winckler, D. Appenroth, C. Fleck, C. Tränkle, J. Lehmann & C. Enzensperger (2014). Beta and gamma carboline derivatives as potential anti-Alzheimer agents: a comparison. Eur. J. Med. Chem. 87, 63-70

U. Hofmann, M. Priem, C. Bartzsch, T. Winckler & K.-H. Feller (2014). A sensitive sensor cell line for the detection of oxidative stress responses in cultured keratinocytes. Sensors (Basel) 14, 11293-11307

Wiegand, S., Seehafer, C., Hofmann, P., Schmith, A., Winckler, T., Meier, D., Földesi, B., Boesle B., Nellen, W., Reimegård, J., Käller, M., Hällmann, J., Emanuelsson, O., Avesson, L., Söderbom, F. & Hammann, C. (2014). The Dictyostelium discoideum RdRP RrpC silences the centromeric retrotransposon DIRS-1 post-transcriptionally and is required for 3' silencing transitivity. Nuc. Acids. Res. 42, 3330-3345

Kreutzer, M.F., Kage, H., Herrmann, J., Pauly, J., Hermenau, R., Müller, R., Hoffmeister, D, Nett M. (2014). Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae. Org Biomol Chem. 12(1), 113-118

2013

Steinchen, W., Lackner, G., Yasmin, S., Schrettl, M., Dahse, H.M., Haas, H., Hoffmeister, D. (2013). Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol. 79(21), 6670-6676

Lackner, G., Bohnert, M., Wick, J., Hoffmeister, D. (2013). Assembly of melleolide antibiotics involves a polyketide synthase with cross-coupling activity. Chem Biol. 20(9), 1101-1106

Pauly, J., Spiteller, D., Linz, J., Jacobs, J., Allen, C., Nett, M., Hoffmeister, D. (2013). Ralfuranone Thioether Production by the Plant Pathogen Ralstonia solanacearum. Chembiochem. 14(16), 2169-2178

Elliott, C.E., Callahan, D.L., Schwenk, S., Nett, M., Hoffmeister, D. & Howlett, B.J. (2013) A gene cluster responsible for biosynthesis of phomenoic acid in the plant pathogenic fungus, Leptosphaeria maculans. Fungal Genet. Biol. 53, 50-58

Kage, H., Kreutzer, M.F., Wackler, B., Hoffmeister, D. & Nett, M. (2013) An iterative type I polyketide synthase initiates the biosynthesis of the antimycoplasma agent micacocidin. Chem. Biol. 20, 764-771.

Kalb, D., Lackner, G. & Hoffmeister, D. (2013) Fungal peptide synthetases: an update on functions and specificity signatures. Fungal Biol. Rev. (accepted)

Schmith, A., Groth, M., Ratka, J., Gatz, S., Spaller, T., Siol, O., Glöckner, G. & Winckler, T. (2013). Conserved gene-regulatory function of the carboxy-terminal domain of dictyostelid C-module-binding factor. Eukaryot. Cell 12, 460-468

Hofmann, U., Michaelis, S., Winckler, T., Wegener, J. & Feller, K.-H. (2013) A whole-cell biosensor as in vitro alternative to skin irritation tests. Biosensors & Bioelectronics 39, 156-162

Forseth, R.R., Amaike, S.A., Schwenk, D., Affeldt, K.J., Hoffmeister, D., Schroeder, F.C. & Keller, N.P. (2013) Homologous non-canonical NRPS gene clusters mediate redundant small-molecule biosynthesis and sclerotia formation in Aspergillus flavus. Angew. Chem. Intl. Ed. 52, 1590-1594

Bohnert, M., Dahse, H.M., Gibson, D.M., Krasnoff, S. & Hoffmeister, D. (2013) The fusarin analogue NG-391 impairs transcription in K-562 leukemia cells. Phytochem. Lett. (akzeptiert)

2012

Lackner, G., Misiek, M., Braesel, J. & Hoffmeister, D. (2012) Genome mining reveals the evolutionary origin and the biosynthetic potential of basidiomycete polyketide synthases. Fungal Genet. Biol. 49, 996-1003

Misiek, M.& Hoffmeister, D. (2012) Sesquiterpene aryl ester natural products in North American Armillaria species. Mycol. Prog. 11, 7-15

Fernandez, E., Ruiz-Duenas, F.J., Ferreira, P.,  Floudas, D., Hibbett, D., Canessa, P., Larrondo, L.F., James, T., Seelenfreund, D., Lobos, S., Polanco, R., Tello, M., Honda , Y., Watanabe, T., Watanabe, T., Ryu, J.S., Kubicek, C.P., Schmoll, M., Gaskell, J., Hammell , K.E., St. John , F., Vanden Wymelenberg, A., Sabat, G., BonDurant, S.S., Syed, K., Yadav, J., Doddapaneni, H., Subramanian, V., Lavín, J.L., Oguiza, J.A., Perez, G., Pisabarro, A.G.,  Ramirez, L., Santoyo, F., Hori, C., Master, E., Coutinho, P.M., Henrissat, B., Lombard, V., Magnuson, J.K., Kües, U., Hori, K., Igarashi, K., Samejima, M., Barry, K., Lapidus, A., Lindquist,  E., Riley, R., Hoffmeister, D., Schwenk, D., Hadar, Y., Yarden, O., de Vries, R., Wiebenga, A., Stenlid, J.,  Eastwood, D., Grigoriev, I., Berka, R., Blanchette, R.A., Kersten, P., Martinez, A.T., Vicuna, R. & Cullen, D. (2012) Comparative genomics of wood decay fungi Phanerochaete chrysosporium and Ceriporiopsis subvermispora provides insight into mechanisms of selective ligninolysis. Proc. Nat. Acad. Sci. USA 109, 5458-5463

Olson, Å., Brandström-Durling, M., Lind, M., Dalman, K., Himmelstrand, K., Karlsson, M., Lundén, K., Vélëz, H., Canbäck, B.,  Högberg, N., Asiegbu, F., Raffaello, T., Martin, F., Kohler, A.-G., Murat, C., Duplessis, S., Morin, E., Lombard, V.,  Coutinho, P., Henrissat, B., Solheim, H., Fossdahl, C.G., Yakovlev, I., Hietala, A., Rouzé, P., Lin, Y.-C., Kües, U.,  Grigoriev, I., Aerts, A., Lindquist E., Salamov, A., Lucas, S., Schmutz, J., Grimwood, J.,  Garbelotto, M., Hoffmeister, D.,  Park, J., Lee, Y.-H., Woodward, S., Deflorio,  G., James,  T., van Diepen, L., Ståhlberg, J., Cullen, D., Belbahri, L.,  De Vries, R., Bouzid, O., Wiebenga, A., Broberg, A., Hansson, D., Gonthier, P. & Stenlid J. (2012) Insight into trade-off between wood  decay and parasitism from the genome of a fungal forest pathogen. New Phytol. 194, 1001-1013

Wackler, B., Lackner, G., Chooi, Y.H. & Hoffmeister, D. (2012) Characterization of the Suillus grevillei quinone synthetase GreA supports a nonribosomal code for α-keto acids. ChemBiochem 13, 1798-1804

M. Espinoza-Moraga, J. Caballero, F. Gaube, T. Winckler & L.S. Santos (2012). 1-Benzyl-1,2,3,4-tetrahydro-β-carboline as channel blocker of N-methyl-D-aspartate receptors. Chem. Biol. Drug Design 79, 594-599

A. Asghar, M. Groth, O. Siol, F. Gaube, C. Enzensperger, G. Glöckner & T. Winckler (2012). Developmental gene regulation by an ancient intercellular communication system in social amoebae. Protist 163, 25-37

2011

T. Winckler, J. Schiefner, T. Spaller & O. Siol (2011). Dictyostelium transfer RNA gene-targeting retrotransposons - Studying mobile element-host interactions in a compact genome. Mobile Genet. Elements 1(2), 145-150

M. Misiek, J. Braesel & D. Hoffmeister (2011). Characterisation of the ArmA adenylation domain implies a more diverse secondary metabolism in the genus Armillaria. Fungal Biol. 115(8), 775-781

D.C. Eastwood, D. Floudas, M. Binder, A. Majcherczyk, P. Schneider, A. Aerts, F.O. Asiegbu, S.E. Baker, K. Barry, M. Bendiksby, M. Blumentritt, P.M. Coutinho, D. Cullen, R.P. de Vries, A. Gathman, B. Goodell, B. Henrissat, K. Ihrmark, H. Kauserud, A. Kohler, K. Labutti, A. Lapidus, J.L. Lavin, Y.H. Lee, E. Lindquis, W. Lilly, S. Lucas, E. Morin, C. Murat, J.A. Oguiza, J. Park, A.G. Pisabarro, R. Riley, A. Rosling, A. Salamov, O. Schmidt, J. Schmutz, I. Skrede, J. Stenlid, A. Wiebenga, X. Xie, U. Kües, D.S. Hibbett, D. Hoffmeister, N. Högberg, F. Martin, I.V. Grigoriev & S.C. Watkinson (2011). The Plant Cell Wall-Decomposing Machinery Underlies the Functional Diversity of Forest Fungi. Science 333, 762-765

M.F. Kreutzer, H. Kage, P. Gebhardt, B. Wackler, H.P. Saluz, D. Hoffmeister & M. Nett (2011). The mic Locus in the Phytopathogen Ralstonia solanacearum Encodes the Biosynthesis of a Complex Yersiniabactin-like Natural Product. Appl Environ Microbiol. 77, 6117-6124

K. Baumgartner, M.P. Coetzee & D. Hoffmeister (2011). Secrets of the subterranean pathosystem of Armillaria. Mol Plant Pathol. 12(6), 515-534.

B. Wackler, P. Schneider, J.M. Jacobs, J. Pauly, C. Allen, M. Nett & D. Hoffmeister (2011). Ralfuranone biosynthesis in Ralstonia solanacearum suggests functional divergence in the quinone synthetase family of enzymes. Chem Biol. 18(3), 354-360.

O. Siol, T. Spaller, J. Schiefner & T. Winckler (2011). Genetically tagged TRE5-A retrotransposons reveal high amplification rates and authentic target site preference in the Dictyostelium discoideum genome. Nuc. Acids Res. 39, 6608-6619

M. Bohnert, M. Miethbauer, H.M. Dahse, J. Ziemen, M. Nett, & D. Hoffmeister (2011). In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects. Bioorg. Med. Chem. Lett. 21, 2003-2006

A. Bilzer, H. Dölz, A. Reinhardt, A. Schmith, O. Siol & T. Winckler (2011). The C-module-binding factor supports the amplification of TRE5-A retrotransposons in the Dictyostelium discoideum genome. Euk. Cell 10, 81-86

D. Robaa, R. Kretschmer, O. Siol, S. AbulAzm, S. Elkhawass, J. Lehmann, & C. Enzensperger (2011). Residues at the indole-NH of LE300 modulate affinities and selectivities for dopamine receptors. Arch. Pharm. (Weinheim), 344(1):28-36

2010

T. Dingermann, T. Winckler & I. Zündorf (2010). Gentechnik - Biotechnik. 2. Auflage. Wissenschaftliche Verlagsgesellschaft Stuttgart, ISBN 978-3-8047-2534-8

Lehrbuch

B. Tewes, B. Frehland, D. Schepmann, K.-U. Schmidtke, T. Winckler & B. Wünsch (2010). Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biolgical evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg. Med. Chem. 18, 8005-8015

M. Bohnert, B. Wackler, B. Hoffmeister, D. (2010). Spotlights on advances in mycotoxin research. Appl. Microbiol. Biotechnol. 87, 1-7.

W. Hüttel, D. Hoffmeister (2010). Chapter 14: Fungal bioconversions in pharmaceutical sciences. In: Hofrichter, U, Esser, K. (Eds.), The Mycota, Vol. X, 2nd  ed.; Springer (im Druck).

Y. Rook, K.-U. Schmidtke, F. Gaube, D. Schepmann, B. Wünsch, J. Heilmann, J. Lehmann & T. Winckler (2010). Bivalent beta-carbolines as potential multi-target anti-Alzheimer agents. J. Med. Chem. 53, 3611-3617

M. Schulze, O. Siol, M. Decker & J. Lehmann (2010). Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: novel heterocyclic templates for butyrylcholinesterase inhibitors. Bioorg. Med. Chem. Lett. 20(9), 2946-2949

M. Schulze, O. Siol, W. Meise, J. Lehmann & C. Enzensperger (2010). Ring expansions of tetrahydroprotoberberines and related dibenzo[c,g]azecines modulate the dopamine receptor subtype affinity and selectivity. Arch. Pharm. 343, 207-214

B. Tewes, B. Frehland, D. Schepmann, K.-U. Schmidtke, T. Winckler & B. Wünsch (2010). Design, synthesis and pharmacological evaluation of 3-benzazepin-1-ols as NR2B-selective NMDA receptor antagenosts. ChemMedChem 5, 687-695

2009

M. Misiek, J. Williams, K. Schmich, W. Hüttel, I. Merfort, C. Salomon, C.A. Aldrich & D. Hoffmeister (2009). Structure and Cytotoxicity of Arnamial and Related Fungal Sesquiterpene Aryl Esters. J. Nat. Prod. 72, 1888-1891.

P. Schneider, J. Jacobs, J. Neres, C.A. Aldrich, C.Z. Allen, M. Nett & D. Hoffmeister (2009) The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen Ralstonia solanacearum, ChemBiochem 10, 2730-2732.

D. Hoffmeister % A. Bechthold (2009). Kapitel 37.12 und 37.13 (Giftpflanzen, Pilzgifte). In: Aktories, K., Förstermann, U., Hofmann, F., Starke, K. (Hrsg.), Pharmakologie und Toxikologie. 10. Auflage; Elsevier, 1098-1117.

D. Hoffmeister & A. Bechthold (2009). Giftpflanzen, Pilzgifte. In: Aktories, K., Förstermann, U., Hofmann, F., Starke, K. (Hrsg.), Repetitorium Pharmakologie und Toxikologie, 2. Aufl., Elsevier, 447-451.

S. Miethbauer, F. Gaube, U. Möllmann, H.-M. Dahse, M. Schmidtke, M. Gareis, M. Pickhardt & B. Liebermann (2009). Antimicrobial,  antiproliferative, cytotoxic, and tau inhibitory activity of rubellins and caeruleoramularin produced by the phytopathogenic fungus Ramularia collo-cygni. Pland Med. 75(14), 1523-1525

J. Lucas, A. Bilzer, L. Moll, I. Zündorf, T. Dingermann, L. Eichinger, O. Siol & T. Winckler (2009). The carboxy-terminal domain of Dictyostelium C-module-binding factor is an independent gene regulatory entity. PLoS ONE 4(4), e5012

S. Miethbauer, F. Gaube, U. Möllmann, H.M. Dahse, M. Schmidtke, M. Gareis, M. Pickhardt & B. Liebermann (2009). Antimicrobial, antiproliferative, cytotoxic, and tau inhibitory activity of rubellins and caeruleoramularin produced by the phytopathogenic fungus Ramularia collo-cygni. Planta Med. 75, 1523-1525

2008

F. Gaube, S. Wölfl, L. Pusch, U. Werner, T.C. Kroll, D. Schrenk, R.W. Hartmann & M. Hamburger (2008). Effects of Leuzea carthamoides on human breast adenocarcinoma MCF-7 cells determined by gene expression profiling and functional assays. Planta Med. 74, 1701-
1708

S. Miethbauer, W. Günther, K.-U. Schmidtke, I. Heiser, S. Gräfe, B. Gitter & B. Liebermann (2008). Uredinorubellins and caeruleoramularin, novel anthraquinone derivatives produced by two species of the genus Ramularia. J. Nat. Prod. 71, 1371-1375

S. Miethbauer, W. Günther, K.-U. Schmidtke, I. Heiser, S. Gräfe, B. Gitter & B.  B, Liebermann B (2008). Uredinorubellins and caeruleoramularin, photodynamically active anthraquinone derivatives produced by two species of the genus ramularia. J. Nat. Prod. 71, 1371-1375

2007

T. Chung, O. Siol, T. Dingermann & T. Winckler (2007). Protein interactions involved in tRNA gene-specific integration of Dictyostelium non-long terminal repeat retrotransposon TRE5-A. Mol. Cell. Biol. 27, 8492-8501

F. Gaube, S. Wölfl, L. Pusch, T.C. Kroll & M. Hamburger (2007). Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7. BMC Pharmacol. 7, 11

2006

P. Schaap, T. Winckler, M. Nelson, E. Alvarez-Curto, B. Elgie, H. Hagiwara, J. Cavender, A. Milano-Curto, D.E. Rozen, T. Dingermann, R. Mutzel & S.L. Baldauf (2006). Molecular phylogeny and evolution of morphology in the social amoebas. Science 314, 661-663

Y. Cheng, B. Schneider, U. Riese, B. Schubert, Z. Li, & M. Hamburger (2006). (+)-N-Deoxymilitarinone A, a neuritogenic pyridone alkaloid from the insect pathogenic fungus Paecilomyces farinosus. J. Nat. Prod. 69, 436-438

O. Siol, M. Boutliliss, T. Chung, G. Glöckner, T. Dingermann & T. Winckler (2006). Role of RNA polymerase III transcription factors in the selection of integration sites by the Dictyostelium non-long terminal repeat retrotransposon TRE5-A. Mol. Cell. Biol. 26, 8242-
8251

S. Miethbauer, S. Haase, K.U. Schmidtke, W. Günther, I. Heiser & B. Liebermann (2006). Biosynthesis of photodynamically active rubellins and structure elucidation of new anthraquinone derivatives produced by Ramularia collo-cygni. Phytochemistry 67, 1206-1213

O. Siol, T. Dingermann & T. Winckler (2006). The C-module DNA-binding factor mediates expression of the Dictyostelium aggregation-specific adenylyl cyclase ACA. Eukaryot. Cell 5, 658-664