Fruchtkörper von Polysphondylium pallidum

Publications Prof. Dr. Thomas Winckler

Fruchtkörper von Polysphondylium pallidum
Foto: Thomas Winckler
2021 Inhalt einblenden
  • S. Schwarthoff, N. Tischer, H. Sager, B. Schätz, M.M. Rohrbach, I. Raztsou, D. Robaa, F. Gaube, H.-D. Arndt, T. Winckler (2021). Evaluation of γ-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors. Bioorg. Med. Chem. 46, 116355
2020 Inhalt einblenden
  • M. Malicki, T. Spaller, T. Winckler, C. Hammann (2020). DIRS retrotransposons amplify via linear, single-stranded cDNA intermediates. Nucleic Acids Res. 48, 4230-4243
2018 Inhalt einblenden
  • C. Chen, D. Bönisch, R. Penzis, T. Winckler & G.K.E. Scriba (2018). Capillary electrophoresis-based enzyme assay for nicotinamide N-methyltransferase. Chromatographia 81, 1439-1444
  • E. Kling, T. Spaller, J. Schiefner, D. Bönisch & T. Winckler (2018). Convergent evolution of integration site selection upstream of tRNA genes by yeast and amoeba retrotransposons. Nucleic Acids Res. 46, 7250-7260
  • D. Heinrich, R. Barnett, L. Tweedy, R. Insall, P. Stallforth & T. Winckler (2018). The chemoattractant glorin is inactivated by ester cleavage during early multicellular development of Polysphondylium pallidum. ACS Chem. Biol. 13, 1506-1513
  • F. Hillmann, G. Forbes, S. Novohradská, I. Ferling, K. Riege, M. Groth, M. Westermann, M. Marz, T. Spaller, T. Winckler, P. Schaap, G. Glöckner (2018). Multiple roots of fruiting body formation in Amoebozoa. Genome Biol. Evol. 10, 591-606
2017 Inhalt einblenden
  • T. Spaller, M. Groth, G. Glöckner & T. Winckler (2017). TRE5-A retrotransposition profiling reveals putative RNA polymerase III transcription complex binding sites on the Dictyostelium extrachromosomal rDNA element. PLoS ONE 12(4): e0175729​
  • R. Barnett, D. Raszkowski, T. Winckler & P. Stallforth (2017). Versatile synthesis of the signaling peptide glorin. Beilstein J. Org. Chem. 13, 247-250
2016 Inhalt einblenden
  • M. Dubiak-Szepietowska, A. Karczmarczyk, T. Winckler & K.-H. Feller (2016). A cell-based biosensor for nanomaterials cytotoxicity assessment in three dimensional cell culture. Toxicology 370, 60-69
  • T. Spaller, E. Kling, G. Glöckner, F. Hillmann & T. Winckler (2016). Convergent evolution of tRNA gene targeting preferences in compact genomes. Mob. DNA 7, 17
  • M. Dubiak-Szepietowska, A. Karczmarczyk, M. Jӧnsson-Niedziółka, T. Winckler & K.-H. Feller (2016). Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicicty assessment in vitro. Toxicol. Appl. Pharmacol. 294, 78-85
2015 Inhalt einblenden
  • P. Schaap, I. Barrantes, P. Minx, N. Sasaki, R.W. Anderson, M. Bénard, K.K. Biggar, N.E. Buchler, R. Bundschuh, X. Chen, C. Fronick, L. Fulton, G. Golderer, N. Jahn, V. Knoop, L. Landweber, C. Maric, D. Miller, A.A. Noegel, R. Peace, G. Pierron, T. Sasaki, M. Schallenberg-Rüdinger, M. Schleicher, R. Singh, T. Spaller, K.B. Storey, T. Suzuki, C. Tomlinson, J.J. Tyson, W.C. Warren, E.R. Werner, G. Werner-Felmayer, R.K. Wilson, T. Winckler, J.M. Gott, G. Glöckner & W. Marwan (2015). The Physarum polycephalum genome reveals extensive use of prokaryotic two-component and metazoan-type tyrosine kinase signaling. Genome Biol. Evol. 8, 109-125
  • A. Schmith, T. Spaller, F. Gaube, Å. Fransson, B. Boesler, S. Ojha, W. Nellen, C. Hammann, F. Söderbom & T. Winckler (2015). A host factor supports retrotransposition of the TRE5-A population in Dictyostelium cells by suppressing an Argonaute protein. Mob. DNA 6, 14
  • R. Otto, R. Penzis, F. Gaube, O. Adolph, K.J. Föhr, P. Warncke, D. Appenroth, C. Fleck, C. Enzensperger, J. Lehmann & T. Winckler (2015). Evaluation of homobivalent carbolines as designed multiple ligands for the treatment of neurodegenerative disorders. J. Med. Chem. 58, 6710-6715
  • B. Tewes, B. Frehland, D. Schepmann, D. Robaa, T. Uengwetwanit, F. Gaube, T. Winckler, W. Sippl & B. Wünsch (2015). Enantiomerically pure 2-methyltetrahydro-3-benzazepin-1-ols selectively blocking GluN2B subunit containing N-methyl-D-aspartate receptors. J. Med. Chem. 58, 6293-6305
  • F. Hillmann, S. Novohradská, D.J. Mattern, T. Forberger, T. Heinekamp, M. Westermann, T. Winckler & A.A. Brakhage (2015). Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation. Environment. Microbiol. 17, 2858-2869
2014 Inhalt einblenden
  • R. Otto, R. Penzis, F. Gaube, T. Winckler, D. Appenroth, C. Fleck, C. Tränkle, J. Lehmann & C. Enzensperger (2014). Beta and gamma carboline derivatives as potential anti-Alzheimer agents: a comparison. Eur. J. Med. Chem. 87, 63-70
  • U. Hofmann, M. Priem, C. Bartzsch, T. Winckler & K.-H. Feller (2014). A sensitive sensor cell line for the detection of oxidative stress responses in cultured keratinocytes. Sensors (Basel) 14, 11293-11307
  • S. Wiegand, C. Seehafer, P. Hofmann, A. Schmith, T. Winckler, D. Meier, B. Földesi, B. Boesler, W. Nellen, J. Reimegård, M. Käller, J. Hällmann, O. Emanuelsson, L. Avesson, F. Söderbom & C. Hammann (2014). The Dictyostelium discoideum RdRP RrpC silences the centromeric retrotransposon DIRS-1 post-transcriptionally and is required for 3' silencing transitivity. Nucleic Acids Res. 42, 3330-3345
2013 Inhalt einblenden
  • T. Winckler (2013). Selfish DNA: a pharmaceutical perspective. Pharmazie 68, 467-473
  • A. Schmith, M. Groth, J. Ratka, S. Gatz, T. Spaller, O. Siol, G. Glöckner & T. Winckler (2013). Conserved gene-regulatory function of the carboxy-terminal domain of dictyostelid C-module-binding factor. Eukaryot. Cell 12, 460-468
  • U. Hofmann, S. Michaelis, T. Winckler, J. Wegener, K.-H. Feller (2013). A whole-cell biosensor as in vitro alternative to skin irritation tests. Biosens. Bioelectron. 39(1), 156-162
2012 Inhalt einblenden
  • M. Espinoza-Moraga, J. Caballero, F. Gaube, T. Winckler, L.S. Santos (2012). 1-Benzyl-1,2,3,4-tetrahydro-β-carboline as channel blocker of N-methyl-D-aspartate receptors. Chem. Biol. Drug Design 79, 594-599
  • A. Asghar, M. Groth, O. Siol, F. Gaube, C. Enzensperger, G. Glöckner & T. Winckler (2012). Developmental gene regulation by an ancient intercellular communication system in social amoebae. Protist 163, 25-37
2011 Inhalt einblenden
  • T. Winckler, J. Schiefner, T. Spaller & O. Siol (2011). Dictyostelium transfer RNA gene-targeting retrotransposons - Studying mobile element-host interactions in a compact genome. Mob. Genet. Elements 1(2), 145-150
  • O. Siol, T. Spaller, J. Schiefner & T. Winckler (2011). Genetically tagged TRE5-A retrotransposons reveal high amplification rates and authentic target site preference in the Dictyostelium discoideum genome. Nucleic Acids Res. 39(15), 6608-6619
  • A. Bilzer, H. Dölz, A. Reinhardt, A. Schmith, O. Siol & T. Winckler (2011). The C-module-binding factor supports the amplification of TRE5-A retrotransposons in the Dictyostelium discoideum genome. Eukaryot. Cell 10, 81-86
2010 Inhalt einblenden
  • B. Tewes, B. Frehland, D. Schepmann, K.-U. Schmidtke, T. Winckler & B. Wünsch (2010). Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg. Med. Chem. 18, 8005-8015
  • Y. Rook, K.-U. Schmidtke, F. Gaube, D. Schepmann, B. Wünsch, J. Heilmann, J. Lehmann & T. Winckler (2010). Bivalent beta-carbolines as potential multi-target anti-Alzheimer agents. J. Med. Chem. 53, 3611-3617
  • B. Tewes, B. Frehland, D. Schepmann, K.-U. Schmidtke, T. Winckler & B. Wünsch (2010). Design, synthesis and pharmacological evaluation of 3-benzazepin-1-ols as NR2B-selective NMDA receptor antagenosts. ChemMedChem 5, 687-695
vor 2010 Inhalt einblenden
  • J. Lucas, A. Bilzer, L. Moll, I. Zündorf, T. Dingermann, L. Eichinger, O. Siol & T. Winckler (2009). The carboxy-terminal domain of Dictyostelium C-module-binding factor is an independent gene regulatory entity. PLoS ONE 4(4), e5012
  • T. Chung, O. Siol, T. Dingermann & T. Winckler (2007). Proteininteractions involved in tRNA gene-specific integration of Dictyostelium non-long terminal repeat retrotransposon TRE5-A. Mol. Cell. Biol. 27, 8492-8501
  • P. Schaap, T. Winckler, M. Nelson, E. Alvarez-Curto, B. Elgie, H. Hagiwara, J. Cavender, A. Milano-Curto, D.E. Rozen, T. Dingermann, R. Mutzel & S.L. Baldauf (2006). Molecular phylogeny and evolution of morphology in the social amoebas. Science 314, 661-663
  • O. Siol, M. Boutliliss, T. Chung, G. Glöckner, T. Dingermann & T. Winckler (2006). Role of RNA polymerase III transcription factors in the selection of integration sites by the Dictyostelium non-long terminal repeat retrotransposon TRE5-A. Mol. Cell. Biol. 26, 8242-8251
  • O. Siol, T. Dingermann & T. Winckler (2006). The C-module DNA-binding factor mediates expression of the Dictyostelium aggregation-specific adenylyl cyclase ACA. Eukaryot. Cell 5, 658-664
  • T. Winckler, I. Zündorf & T. Dingermann (2005). An NIH model organism for biopharmaceutical and biomedical research: the lower eukaryote Dictyostelium discoideum; in: Modern Biopharmaceuticals - Design, Development and Optimization (Vol. 2), J. Knäblein (ed.), Wiley VCH, pp.661-693
  • T. Winckler, K. Szafranski & G. Glöckner (2005). Transfer RNA gene-targeted integration: an adaptation of retrotransposable elements to survive in the compact Dictyostelium discoideum genome. Cytogenet. Genome Res. 110, 288-298
  • L. Eichinger, J.A. Pachebat, G. Glöckner, M.-A. Rajandream, R. Sucgang, M. Berriman, J. Song, R. Olsen, K. Szafranski, Q. Xu, B. Tunggal, S. Kummerfeld, M. Madera, B. A. Konfortov, F. Rivero, A. T. Bankier, R. Lehmann, N. Hamlin, R. Davies, P. Gaudet, P. Fey, K. Pilcher, G. Chen, D. Saunders, E. Sodergren, P. Davis, A. Kerhornou, X. Nie, N. Hall, C. Anjard, L. Hemphill, N. Bason, P. Farbrother, B. Desany, E. Just, T. Morio, R. Rost, C. Churcher, J. Cooper, S. Haydock, N. van Driessche, A. Cronin, I. Goodhead, D. Muzny, T. Mourier, A. Pain, M. Lu, D. Harper, R. Lindsay, H. Hauser, K. James, M. Quiles, M. Madan Babu, T. Saito, C. Buchrieser, A. Wardroper, M. Felder, M. Thangavelu, D. Johnson, A. Knights, H. Loulseged, K. Mungall, K. Oliver, C. Price, M.A. Quail, H. Urushihara,  J. Hernandez, E. Rabbinowitsch, D. Steffen, M. Sanders, J. Ma, Y. Kohara, S. Sharp, M. Simmonds, S. Spiegler, A. Tivey, S. Sugano, B. White, D. Walker, J. Woodward, T. Winckler, Y. Tanaka, G. Shaulsky, M. Schleicher, G. Weinstock, A. Rosenthal, E.C. Cox, R. L. Chisholm, R. Gibbs, W. F. Loomis, M. Platzer, R. R. Kay, J. Williams, P. H. Dear, A.A. Noegel, B. Barrell & A. Kuspa (2005). The genome of the social amoeba Dictyostelium discoideum. Nature 435, 43-57
  • T. Winckler, N. Iranfar, P. Beck, I. Jennes, O. Siol, U. Baik, W.F. Loomis & T. Dingermann (2004). CbfA, the C-module DNA-binding factor, plays an essential role in the initiation of Dictyostelium discoideum development. Eukaryot. Cell 3, 1349-1358
  • K. Szafranski, T. Dingermann, G. Glöckner & T. Winckler (2004). Template jumping by a Dictyostelium LINE reverse transcriptase created a SINE-like 5S rRNA retropseudogene. Mol. Gen. Genomics 271, 98-102
  • K. Dannat, J. Tillner, T. Winckler, M. Weiß, K. Eger, & T. Dingermann (2003). The effects of medicinal compounds on the differentiation of the eukaryotic microorganism Dictyostelium discoideum: Can this method be used as a screening test for reproductive toxicity in humans? Pharmazie 58, 204-210
  • T. Winckler, T. Dingermann & G. Glöckner (2002). Dictyostelium mobile elements - strategies to amplify in a compact genome. Cell. Mol. Life Sci. 59, 2097-2111
  • G. Glöckner, L. Eichinger, K. Szafranski, J.A. Pachebat, A.T. Bankier, P.H. Dear, R. Lehmann, C. Baumgart, G. Parra, J.F. Abril, R. Guigó, K. Kumpf, B.Tunggal, the Dictyostelium Genome Sequencing Consortium (u.a. T. Winckler), E. Cox, M.A. Quail, M. Platzer, A. Rosenthal & A.A. Noegel (2002). Sequence and analysis of chromosome 2 of Dictyostelium discoideum. Nature 418, 79-85
  • A. Friese, K. Hell-Momeni, I. Zündorf, T. Winckler, T. Dingermann & G. Dannhardt (2002). Synthesis and biological evaluation of cycloalkylidene carboxylic acids as novel effectors of Ras/Raf interaction. J. Med. Chem. 45, 1535-1542
  • P. Beck, T. Dingermann & T. Winckler (2002). Transfer RNA gene-targeted retrotransposition of Dictyostelium TRE5-A into a chromosomal UMP synthase gene trap. J. Mol. Biol. 318, 273-285
  • U. Hentschel, I. Zündorf, T. Dingermann & T. Winckler (2001). On the problem of establishing the subcellular localization of Dictyostelium retrotransposon TRE5-A proteins by biochemical analysis of nuclear extracts.  Anal. Biochem. 296, 83-91
  • T. Winckler, C. Trautwein, C. Tschepke, C. Neuhäuser, I. Zündorf, G. Vogel & T. Dingermann (2001). Gene function analysis by amber stop codon suppression: CMBF is a nuclear protein that supports growth and development of Dictyostelium amoebae. J. Mol. Biol. 305, 703-714
  • G. Glöckner, K. Szafranski, T. Winckler, T. Dingermann, M. Quail, E. Cox, L. Eichinger, A.A. Noegel & A. Rosenthal (2001). The complex repeats of Dictyostelium discoideum. Genome Res. 11, 585-594
  • J. Horn, A. Dietz-Schmidt, I. Zündorf, J. Garin, T. Dingermann & T. Winckler (1999). A Dictyostelium protein binds to distinct oligo(dA)•oligo(dT) DNA sequences in the C-module of the retrotransposable element DRE. Eur. J. Biochem. 265, 441-448
  • K. Szafranski, G. Glöckner, T. Dingermann, A.A. Noegel, L. Eichinger, A. Rosenthal & T. Winckler (1999). Non-LTR retrotransposons with unique integration preferences downstream of Dictyostelium discoideum transfer RNA genes. Mol. Gen. Genet. 262, 772-780
  • H.-T. Wolf, T. van den Berg, F.-C. Czygan, A. Mosandl, T. Winckler, I. Zündorf & T. Dingermann (1999). Identification of Melissa officinalis subspecies by DNA fingerprinting. Planta Med. 65, 83-85
  • H.-T. Wolf, I. Zündorf, T. Winckler, R. Bauer & T. Dingermann (1999). Characterization of Echinacea species and detection of possible adulterations by RAPD analysis. Planta Med. 65, 773-774
  • T. Winckler (1998). Retrotransposable elements in the Dictyostelium discoideum genome. Cell. Mol. Life Sci. 54, 383-393
  • T. Winckler, C. Tschepke., E.L. de Hostos, A. Jendretzke & T. Dingermann (1998). Tdd-3, a transfer RNA gene-associated poly(A) retrotransposon from Dictyostelium discoideum. Mol. Gen. Genet. 257, 655-661
  • J. Tillner, H. Nau, T. Winckler & T. Dingermann (1998). Evaluation of the teratogenic potential of valproic acid analogues in transgenic Dictyostelium discoideum strains. Toxicol. in Vitro 12, 463-469
  • G. Voith, H. Kramm, I. Zündorf, T. Winckler & T. Dingermann (1998). Expression of the rat muscarinic receptor gene m3 in Dictyostelium discoideum. Pharmazie 53, 707-710
  • M. Bukenberger, J. Horn, T. Dingermann, R.P. Dottin & T. Winckler (1997). Molecular cloning of a cDNA encoding nucleosome core histone H3 from Dictyostelium discoideum by genetic selection in yeast. Biochim. Biophys. Acta 1352, 85-90
  • A. Geier, J. Horn, T. Dingermann & T. Winckler (1996). A nuclear protein factor binds to the 3' regulatory module of the long-interspersed-nuclear-element-like Dictyostelium repetitive element. Eur. J. Biochem. 241, 70-76
  • J. Tillner, T. Winckler & T. Dingermann (1996). Developmentally regulated promoters from Dictyostelium discoideum as molecular markers for testing potential teratogens. Pharmazie 51, 902-906
  • M. Bukenberger, T. Dingermann, W. Meissner, K.H. Seifart & T. Winckler (1994). Isolation of transcription factor IIIC from Dictyostelium discoideum. Eur. J. Biochem. 220, 839-846
  • J. Tillner, T. Winckler & T. Dingermann (1994). A simple cytotoxicity assay using the eucaryotic microorganism Dictyostelium discoideum. Pharmazie 49, 759-761
  • J. Hofmann, T. Winckler, A. Hanenkamp, M. Bukenberger, G. Schumann, R. Marschalek & Dingermann, T. (1993). The Dictyostelium discoideum 5S rDNA is organized in the same transcriptional orientation as the other rDNAs. Biochem. Biophys. Res. Comm.191, 558-564
  • H. Troll, T. Winckler, I. Lascu, N. Müller, W. Saurin, M. Véron & R. Mutzel (1993). Separate nuclear genes encode cytosolic and mitochondrial nucleoside diphosphate kinase in Dictyostelium discoideum. J. Biol. Chem. 268, 25469-2547
  • M.-N. Simon, T. Winckler, R. Mutzel, M. Véron & J.C.C. Maia (1992). Serine/threonine protein phosphatases in Dictyostelium discoideum: No evidence for type 1 activity. Biochem. Biophys. Res. Comm. 184, 1142-1151
  • T. Winckler, H. Dammann & Mutzel, R. (1991). Ca2+/calmodulin-binding proteins in Dictyostelium discoideum. Res. Microbiol. 142, 509-519
  • J. Sonnemann, A. Bäuerle, T. Winckler & R. Mutzel (1991). A ribosomal calmodulin-binding protein from Dictyostelium. J. Biol. Chem. 266, 23091-23096
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