HPLC

Publikationen

HPLC
Foto: Janis Fricke
Weitere Publikationen der Arbeitsgruppe Prof. Dr. Dirk Hoffmeister
2019 Inhalt einblenden
  • König S, Romp E, Krauth V, Rühl M, Dörfer M, Liening S, Hoffmann B, Häfner AK, Steinhilber D, Karas M, Garscha U, Hoffmeister D, Werz O (2019) Melleolides from honey mushroom inhibit 5-lipoxygenase via Cys159. Cell Chem Biol 26, 60-70.
  • Baldeweg F, Hoffmeister D, Nett M (2019) A genomics perspective on natural product biosynthesis in plant pathogenic bacteria. Nat Prod Rep 36, 307-325.
  • Fricke J, Lenz C, Wick J, Blei F, Hoffmeister D (2019) Production options for psilocybin - The making of the magic. Chem Eur J 25, 897-903.
  • Baldeweg F, Warncke P, Fischer D, Gressler M (2019) Fungal Biosurfactants from Mortierella alpina. Org Lett 21, 1444-1448.
  • Dörfer M, Heine D, König S, Gore S, Werz O, Hertweck C, Gressler M, Hoffmeister D (2019) Melleolides impact fungal translation via Elongation Factor 2. Org Biomol Chem 17, 4906-4916.
  • Fricke J, Sherwood A, Kargbo R, Orry A, Blei F, Naschberger A, Rupp B, Hoffmeister D (2019) Enzymatic route toward 6-methylated baeocystin and psilocybin. ChemBioChem 20, 2824-2829.
  • Baccile JA, Le HH, Pfannenstiel B, Bok JW, Gomez C, Brandenburger E, Hoffmeister D, Keller NP, Schroeder FC (2019) Diketopiperazine Formation in Gliotoxin Biosynthesis Requires Dedicated Cyclization and Thiolation Domains. Angew Chem Intl Ed 58, 14589-14593.
  • Dörfer M, Gressler, M, Hoffmeister D (2019) Diversity and bioactivity of Armillaria sesquiterpene aryl ester natural products. Mycol Prog 18, 1027-1037.
2018 Inhalt einblenden
  • Tauber JP, Gallegos-Monterrosa R, Kovacs AT, Shelest E, Hoffmeister D (2018) Dissimilar pigment regulation in Serpula lacrymans and Paxillus involutus during interkingdom interactions. Microbiology 164, 65-77.
  • Tauber JP, Matthaeus C, Lenz C, Hoffmeister D, Popp J (2018) Analysis of basidiomycete pigments in situ by Raman spectroscopy. J Biophoton 11, e201700369.
  • Brandenburger E, Braga D,  Kombrink A, Lackner G, Gressler J, Künzler M,  Hoffmeister D (2018) Multi-genome analysis identifies functional and phylogenetic diversity of basidiomycete adenylate-forming reductases. Fungal Genet Biol 112, 55-63.
  • Blei F, Baldeweg F, Fricke J, Hoffmeister D (2018) Biocatalytic production of psilocybin and derivatives in tryptophan synthase-enhanced reactions. Chem Eur J 24, 10028-10031.
  • Hoefgen S, Lin J, Fricke J, Stroe MC, Mattern DJ, Kufs JE, Hortschansky P, Brakhage AA, Hoffmeister D, Valiante V (2018) Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi. Metab Eng 48, 44-51.
  • Held BW, Hoffmeister D, Blanchette RA (2018) Occurrence of European Tar Spot (Rhytisma acerinum) on Norway Maple causing severe infections in Minnesota. Plant Disease 102, 12.
  • Blei F, Fricke J, Wick J, Slot JC, Hoffmeister D (2018) Iterative L-tryptophan methylation in Psilocybe evolved by sub-domain duplication. Chembiochem 19, 2160-2166.
2017 Inhalt einblenden
  • Lenz C, Wick J, Hoffmeister D (2017) Identification of N-Methyl-4-hydroxytryptamine (Norpsilocin) as a Psilocybe Natural Product. J Nat Prod 80, 2835-2838.
  • Baldeweg F, Kage H, Schieferdecker S, Allen C, Hoffmeister D, Nett M (2017) Structure of ralsolamycin, the inter-kingdom morphogen of the crop plant pathogen Ralstonia solanacearum GMI1000. Org Lett 19, 4868-4871.
  • Brandt P, Garcia-Altares M, Nett M, Hertweck C, Hoffmeister D (2017) Induced chemical defense of a mushroom by a double bond-shifting polyene synthase. Angew Chem Intl Ed 56, 5937-5941.
  • Braesel J, Fricke J, Schwenk D, Hoffmeister D (2017) Biochemical and genetic basis of orsellinic acid biosynthesis and prenylation in a stereaceous basidiomycete. Fungal Genet Biol 98, 12-19.
  • Zhu Y, Mahaney J, Jellison J, Cao J, Gressler J, Hoffmeister D, Goodell B (2017) Fungal variegatic acid and extracellular polysaccharides promote the site specific generation of reactive oxygen species. J Ind Microbiol Biotechnol 44, 329-338.
  • Fricke J, Blei F, Hoffmeister D (2017) Enzymatic synthesis of psilocybin. Angew Chem Intl Ed 56, 12352-12355.
  • Brandenburger E, Gressler M, Leonhardt R, Lackner G, Habel A, Hertweck C, Brock M, Hoffmeister D (2017) A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. Appl Environ Microbiol 83, e01478-17.
2016 Inhalt einblenden
  • Kalb D, Gressler J, Hoffmeister D (2016) Active-Site Engineering Expands the Substrate Profile of the Basidiomycete L-Tryptophan Decarboxylase CsTDC. ChemBioChem 17, 132-136. 
  • Shah F, Nicolas C, Bentzer J, Ellström M, Smits M, Rineau F, Canbäck B, Floudas D, Carleer R, Lackner G, Braesel J, Hoffmeister D, Henrissat B, Ahrén D, Johansson T, Hibbett DS, Martin F, Persson P, Tunlid A (2016) Ectomycorrhizal fungi decompose litter material using oxidative mechanisms adapted from saprotrophic ancestors. New Phytol 209, 1705-1719. 
  • Shah F, Schwenk D, Nicolas C, Persson P, Hoffmeister D, Tunlid A (2016) Involutin is a Fe3+ reductant Secreted by the Ectomycorrhizal Fungus Paxillus involutus during Fenton-based Decomposition of Organic Matter. Appl Environ Microbiol 81, 8427-8433. 
  • Baccile JA, Spraker JE, Le HH, Brandenburger E, Gomez C, Bok JW, Macheleidt J, Brakhage AA, Hoffmeister D, Keller NP, Schroeder FC (2016) Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatusNat Chem Biol 12, 419-424.
  • Schwenk D, Brandt P, Blanchette R, Nett M, Hoffmeister D (2016) Unexpected metabolic versatility in a combined fungal fomannoxin/vibralactone biosynthesis. J Nat Prod 79, 1407-1414.
  • Kalb D, Heinekamp T, Schieferdecker S, Nett M, Brakhage AA, Hoffmeister D (2016) An iterative O-methyltransferase catalyzes 1,11-dimethylation of Aspergillus fumigatus fumaric acid amides. ChemBioChem 17, 1813-1817.
  • Schlegel M, Münsterkötter M, Güldener U, Bruggmann R, Duo A, Hainaut M, Henrissat B, Sieber CM, Hoffmeister D, Grünig CR (2016) Globally distributed root endophyte Phialocephala subalpina links pathogenic and saprophytic lifestyles. BMC Genomics 17, 1015.
  • Braga D, Hoffmeister D, Nett M (2016) A non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis. Beilstein J Org Chem 12, 2766-2770.
  • Tauber JP, Schroeckh V, Shelest E, Brakhage AA, Hoffmeister D (2016) Bacteria induce pigment formation in the basidiomycete Serpula lacrymansEnviron Microbiol 18, 5218-5227.
2015 Inhalt einblenden
  • Braesel J, Götze S, Shah F, Heine D, Tauber J, Hertweck C, Tunlid A, Stallforth P, Hoffmeister D (2015) Three redundant synthetases secure redox-active pigment production in the basidiomycete Paxillus involutusChem Biol 22, 1325-1334.
  • Kalb D, Heinekamp T, Lackner G, Scharf DH, Dahse H-M, Brakhage AA, Hoffmeister D (2015) Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatusAppl Environ Microbiol 81, 1594-1600. 
  • Kalb D, Lackner G, Rappe M, Hoffmeister D (2015) Activity of α-aminoadipate reductase depends on the N-terminally extending domain. Chembiochem 16, 1426-1430. 
  • Karlsson M, Durling MB, Choi J, Kosawang C, Lackner G, Tzelepis GD, Nygren K, Dubey MK, Kamou N, Levasseur A, Zapparata A, Wang J, Amby DB, Jensen B, Sarrocco S, Panteris E, Lagopodi AL, Pöggeler S, Vannacci G, Collinge DB, Hoffmeister D, Henrissat B, Lee YH, Jensen DF (2015) Insights on the Evolution of Mycoparasitism from the Genome of Clonostachys roseaGenome Biol Evol 7, 465-480. 
  • Stadler M, Hoffmeister D (2015) Fungal natural products-the mushroom perspective. Front Microbiol 6, 127. 
  • Wick J, Heine D, Lackner G, Misiek M, Tauber J, Jagusch H, Hertweck C, Hoffmeister D (2015) A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (honey mushroom) toxins. Appl Environ Microbiol 82, 1196-1204.
2014 Inhalt einblenden
  • Bohnert M, Nützmann HW, Schroeckh V, Horn F, Dahse HM, Brakhage AA, Hoffmeister D (2014) Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure-activity relationships. Phytochemistry 105, 101-108. 
  • Bohnert M, Scherer O, Wiechmann K, König S, Dahse HM, Hoffmeister D, Werz O (2014) Melleolides induce rapid cell death in human primary monocytes and cancer cells. Bioorg Med Chem 22, 3856-3861. 
  • Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse HM, Hoffmeister D, Hertweck C (2014) Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion. Angew Chem Int Ed Engl 53, 13409-13413. 
  • Hori C, Ishida T, Igarashi K, Samejima M, Suzuki H, Master E, Ferreira P, Ruiz-Dueñas FJ, Held B, Canessa P, Larrondo LF, Schmoll M, Druzhinina IS, Kubicek CP, Gaskell JA, Kersten P, St John F, Glasner J, Sabat G, Splinter BonDurant S, Syed K, Yadav J, Mgbeahuruike AC, Kovalchuk A, Asiegbu FO, Lackner G, Hoffmeister D, Rencoret J, Gutiérrez A, Sun H, Lindquist E, Barry K, Riley R, Grigoriev IV, Henrissat B, Kües U, Berka RM, Martínez AT, Covert SF, Blanchette RA, Cullen D (2014) Analysis of the Phlebiopsis gigantea Genome, Transcriptome and Secretome Provides Insight into Its Pioneer Colonization Strategies of Wood. PLoS Genet 10, e1004759. 
  • Kalb D, Lackner G, Hoffmeister D (2014) Functional and phylogenetic divergence of fungal adenylate-forming reductases. Appl Environ Microbiol 80, 6175-6183. 
  • Kreutzer MF, Kage H, Herrmann J, Pauly J, Hermenau R, Müller R, Hoffmeister D, Nett M (2014) Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniaeOrg Biomol Chem 12, 113-118. 
  • Pauly J, Nett M, Hoffmeister D (2014) Ralfuranone is produced by an alternative aryl-substituted γ-lactone biosynthetic route in Ralstonia solanacearumJ Nat Prod 77, 1967-1971. 
  • Sasso S, Shelest E, Hoffmeister D (2014) Comments on the distribution and phylogeny of type I polyketide synthases and nonribosomal peptide synthetases in eukaryotes. Proc Natl Acad Sci USA 111, E3946. 
  • Schwenk D, Nett M, Dahse H-M, Horn U, Blanchette RA, Hoffmeister D (2014) Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete J Nat Prod 77, 2658-2663.
2013 Inhalt einblenden
  • Bohnert M, Dahse HM, Gibson DM, Krasnoff S, Hoffmeister D (2013) The fusarin analogue NG-391 impairs transcription in K-562 leukemia cells. Phytochemistry Letters 6, 189-192.
  • Elliott CE, Callahan DL, Schwenk D, Nett M, Hoffmeister D, Howlett BJ (2013) A gene cluster responsible for biosynthesis of phomenoic acid in the plant pathogenic fungus, Leptosphaeria maculansFungal Genet Biol 53, 50-58. 
  • Forseth RR, Amaike S, Schwenk D, Affeldt KJ, Hoffmeister D, Schroeder FC, Keller NP (2013) Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavusAngew Chem Int Ed Engl 52, 1590-1594. 
  • Kage H, Kreutzer MF, Wackler B, Hoffmeister D, Nett M (2013) An iterative type I polyketide synthase initiates the biosynthesis of the antimycoplasma agent micacocidin. Chem Biol 20, 764-771. 
  • Kalb D, Lackner G, Hoffmeister D (2013) Fungal peptide synthetases – an update on functions and specificity signatures. Fungal Biology Reviews 27, 43-50. (Review) 
  • Lackner G, Bohnert M, Wick J, Hoffmeister D (2013) Assembly of melleolide antibiotics involves a polyketide synthase with cross-coupling activity. Chem Biol 20, 1101-1106. 
  • Pauly J, Spiteller D, Linz J, Jacobs J, Allen C, Nett M, Hoffmeister D (2013) Ralfuranone thioether production by the plant pathogen Ralstonia solanacearumChembiochem 14, 2169-2178. 
  • Steinchen W, Lackner G, Yasmin S, Schrettl M, Dahse HM, Haas H, Hoffmeister D (2013) Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen Aspergillus fumigatusAppl Environ Microbiol 79, 6670-6676.
2012 Inhalt einblenden
  • Fernandez-Fueyo E, Ruiz-Dueñas FJ, Ferreira P, Floudas D, Hibbett DS, Canessa P, Larrondo LF, James TY, Seelenfreund D, Lobos S, Polanco R, Tello M, Honda Y, Watanabe T, Watanabe T, Ryu JS, San RJ, Kubicek CP, Schmoll M, Gaskell J, Hammel KE, St John FJ, Vanden Wymelenberg A, Sabat G, Splinter BonDurant S, Syed K, Yadav JS, Doddapaneni H, Subramanian V, Lavín JL, Oguiza JA, Perez G, Pisabarro AG, Ramirez L, Santoyo F, Master E, Coutinho PM, Henrissat B, Lombard V, Magnuson JK, Kües U, Hori C, Igarashi K, Samejima M, Held BW, Barry KW, LaButti KM, Lapidus A, Lindquist EA, Lucas SM, Riley R, Salamov AA, Hoffmeister D, Schwenk D, Hadar Y, Yarden O, de Vries RP, Wiebenga A, Stenlid J, Eastwood D, Grigoriev IV, Berka RM, Blanchette RA, Kersten P, Martinez AT, Vicuna R, Cullen D (2012) Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis. Proc Natl Acad Sci USA 109, 5458-5463. 
  • Lackner G, Misiek M, Braesel J, Hoffmeister D (2012) Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases. Fungal Genet Biol 49, 996-991003. 
  • Misiek M, Hoffmeister D (2012) Sesquiterpene aryl ester natural products in North American Armillaria species. Mycol Progress 11, 7-15. 
  • Olson A, Aerts A, Asiegbu F, Belbahri L, Bouzid O, Broberg A, Canbäck B, Coutinho PM, Cullen D, Dalman K, Deflorio G, van Diepen LT, Dunand C, Duplessis S, Durling M, Gonthier P, Grimwood J, Fossdal CG, Hansson D, Henrissat B, Hietala A, Himmelstrand K, Hoffmeister D, Högberg N, James TY, Karlsson M, Kohler A, Kües U, Lee YH, Lin YC, Lind M, Lindquist E, Lombard V, Lucas S, Lundén K, Morin E, Murat C, Park J, Raffaello T, Rouzé P, Salamov A, Schmutz J, Solheim H, Ståhlberg J, Vélëz H, de Vries RP, Wiebenga A, Woodward S, Yakovlev I, Garbelotto M, Martin F, Grigoriev IV, Stenlid J (2012) Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen. New Phytol 194, 1001-1013. 
  • Wackler B, Lackner G, Chooi YH, Hoffmeister D (2012) Characterization of the Suillus grevillei quinone synthetase GreA supports a nonribosomal code for aromatic α-keto acids.Chembiochem 13, 1798-1804.
2011 Inhalt einblenden
  • Baumgartner K, Coetzee MP, Hoffmeister D (2011) Secrets of the subterranean pathosystem of ArmillariaMol Plant Pathol 12, 515-534.
  • Bohnert M, Miethbauer S, Dahse HM, Ziemen J, Nett M, Hoffmeister D (2011) In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects. Bioorg Med Chem Lett 21, 2003-2006. 
  • Eastwood DC, Floudas D, Binder M, Majcherczyk A, Schneider P, Aerts A, Asiegbu FO, Baker SE, Barry K, Bendiksby M, Blumentritt M, Coutinho PM, Cullen D, de Vries RP, Gathman A, Goodell B, Henrissat B, Ihrmark K, Kauserud H, Kohler A, LaButti K, Lapidus A, Lavin JL, Lee YH, Lindquist E, Lilly W, Lucas S, Morin E, Murat C, Oguiza JA, Park J, Pisabarro AG, Riley R, Rosling A, Salamov A, Schmidt O, Schmutz J, Skrede I, Stenlid J, Wiebenga A, Xie X, Kües U, Hibbett DS, Hoffmeister D, Högberg N, Martin F, Grigoriev IV, Watkinson SC (2011) The plant cell wall-decomposing machinery underlies the functional diversity of forest fungi. Science 333, 762-765. 
  • Kreutzer MF, Kage H, Gebhardt P, Wackler B, Saluz HP, Hoffmeister D, Nett M (2011) Biosynthesis of a complex yersiniabactin-like natural product via the mic locus in phytopathogen Ralstonia solanacearumAppl Environ Microbiol 77, 6117-6124. 
  • Misiek M, Braesel J, Hoffmeister D (2011) Characterisation of the ArmA adenylation domain implies a more diverse secondary metabolism in the genus ArmillariaFungal Biol 115, 775-781. 
  • Wackler B, Schneider P, Jacobs JM, Pauly J, Allen C, Nett M, Hoffmeister D (2011) Ralfuranone biosynthesis in Ralstonia solanacearum suggests functional divergence in the quinone synthetase family of enzymes. Chem Biol 18, 354-360.
2010 und früher Inhalt einblenden
  • Bohnert M, Wackler B, Hoffmeister D (2010) Spotlights on advances in mycotoxin research. Appl Microbiol Biotechnol 87, 1-7.
  • Misiek M, Williams J, Schmich K, Hüttel W, Merfort I, Salomon CE, Aldrich CC, Hoffmeister D (2009) Structure and cytotoxicity of arnamial and related fungal sesquiterpene aryl esters. J Nat Prod 72, 1888-1891.
  • Schneider P, Jacobs JM, Neres J, Aldrich CC, Allen C, Nett M, Hoffmeister D (2009) The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen Ralstonia solanacearumChembiochem 10, 2730-2732. 
  • Misiek M, Hoffmeister D (2008) Processing sites involved in intron splicing of Armillaria natural product genes. Mycol Res 112, 216-224. 
  • Schneider P, Bouhired S, Hoffmeister D (2008) Characterization of the atromentin biosynthesis genes and enzymes in the homobasidiomycete Tapinella panuoidesFungal Genet Biol 45, 1487-1496. 
  • Schneider P, Weber M, Hoffmeister D (2008) The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones. Fungal Genet Biol 45, 302-309. 
  • Bouhired S, Weber M, Kempf-Sontag A, Keller NP, Hoffmeister D (2007) Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genet Biol 44, 1134-1145. 
  • Hoffmeister D, Keller NP (2007) Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep 24, 393-416. 
  • Misiek M, Hoffmeister D (2007) Fungal genetics, genomics, and secondary metabolites in pharmaceutical sciences. Planta Med 73, 103-115. 
  • Schneider P, Weber M, Rosenberger K, Hoffmeister D (2007) A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones. Chem Biol 14, 635-644. 
  • Bok JW, Hoffmeister D, Maggio-Hall LA, Murillo R, Glasner JD, Keller NP (2006) Genomic mining for Aspergillus natural products. Chem Biol 13, 31-37. 
  • Chen YH, Wang CC, Greenwell L, Rix U, Hoffmeister D, Vining LC, Rohr J, Yang KQ (2005) Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase. J Biol Chem 280, 22508-22514. 
  • Luzhetskyy A, Zhu L, Gibson M, Fedoryshyn M, Dürr C, Hofmann C, Hoffmeister D, Ostash B, Mattingly C, Adams V, Fedorenko V, Rohr J, Bechthold A (2005) Generation of novel landomycins M and O through targeted gene disruption. Chembiochem 6, 675-678. 
  • Dürr C, Hoffmeister D, Wohlert SE, Ichinose K, Weber M, Von Mulert U, Thorson JS, Bechthold A (2004) The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew Chem Int Ed Engl 43, 2962-2965. 
  • Hoffmeister D, Thorson JS (2004) Mechanistic implications of Escherichia coli galactokinase structure-based engineering. Chembiochem 5, 989-992. 
  • Hoffmeister D, Weber M, Dräger G, Ichinose K, Dürr C, Bechthold A (2004) Rational saccharide extension by using the natural product glycosyltransferase LanGT4. Chembiochem 5, 369-371. 
  • Thorson JS, Barton WA, Hoffmeister D, Albermann C, Nikolov DB (2004) Structure-based enzyme engineering and its impact on in vitro glycorandomization. Chembiochem 5, 16-25. 
  • Hoffmeister D, Dräger G, Ichinose K, Rohr J, Bechthold A (2003) The C-Glycosyltransferase UrdGT2 is unselective toward D- and L-configured nucleotide-bound rhodinoses. J Am Chem Soc 125, 4678-4679. 
  • Hoffmeister D, Yang J, Liu L, Thorson JS (2003) Creation of the first anomeric D/L-sugar kinase by means of directed evolution. Proc Natl Acad Sci USA 100, 13184-13189. 
  • Pelzer S, Hoffmeister D, Merfort I, Bechthold A (2003) Procaryotic and eucaryotic cells in biotech production In: Kayser O, Müller R. H. (eds.) Pharmaceutical Biotechnology, Drug Discovery and Clinical Applications pp. 9-33. Wiley-Blackwell. 
  • Rebets Y, Ostash B, Luzhetskyy A, Hoffmeister D, Brana A, Mendez C, Salas JA, Bechthold A, Fedorenko V (2003) Production of landomycins in Streptomyces globisporus 1912 and S. cyanogenus S136 is regulated by genes encoding putative transcriptional activators. FEMS Microbiol Lett 222, 149-153. 
  • Rix U, Remsing LL, Hoffmeister D, Bechthold A, Rohr J (2003) Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem 4, 109-111. 
  • Hoffmeister D, Wilkinson B, Foster G, Sidebottom PJ, Ichinose K, Bechthold A (2002) Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol 9, 287-295. 
  • Hoffmeister D, Ichinose K, Bechthold A (2001) Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity. Chem Biol 8, 557-567. 
  • Weitnauer G, Mühlenweg A, Trefzer A, Hoffmeister D, Süssmuth RD, Jung G, Welzel K, Vente A, Girreser U, Bechthold A (2001) Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics. Chem Biol 8, 569-581. 
  • Faust B, Hoffmeister D, Weitnauer G, Westrich L, Haag S, Schneider P, Decker H, Künzel E, Rohr J, Bechthold A (2000) Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tü2717. Microbiology 146, 147-154. 
  • Hoffmeister D, Ichinose K, Domann S, Faust B, Trefzer A, Dräger G, Kirschning A, Fischer C, Künzel E, Bearden D, Rohr J, Bechthold A (2000) The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster. Chem Biol 7, 821-831. 
  • Trefzer A, Hoffmeister D, Künzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A (2000) Function of glycosyltransferase genes involved in urdamycin A biosynthesis. Chem Biol 7, 133-142.
Diese Seite teilen
Die Uni Jena in den sozialen Medien:
Ausgezeichnet studieren:
  • Logo der Initiative "Total E-Quality"
  • Logo des Best Practice-Club "Familie in der Hochschule"
  • Logo des Projekts "Partnerhochschule des Spitzensports"
  • Qualitätssiegel der Stiftung Akkreditierungsrat - System akkreditiert
Zurück zum Seitenanfang